Biapenem Powder

Biapenem Powder
Details
Product Name: Biapenem Powder
Alternative Names: (4R,5S,6S)-3-[[(3S,5S)-5-(carbamoylmethyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, DHP-I stable carbapenem lab raw powder
Specification: HPLC ≥98.0%, research grade, adjustable purity available
CAS No.: 120410-24-4
Appearance: White to off-white crystalline powder. Freely soluble in purified water and aqueous buffer, slightly soluble in methanol. The bicyclic β-lactam ring shows inherent resistance against DHP-I enzymatic hydrolysis. Keep under anhydrous and dim ambient conditions.
Core Advantages: Low-temperature controlled crystallization protects the β-lactam ring structure from hydrolysis. Heavy metal and residual solvent tests follow antibiotic research standards. Broad-spectrum antibacterial potency remains stable across batches. Full related-substance profiling and mass spectral identification are provided per lot. Compatible with bacterial susceptibility culture medium to support in-vitro carbapenem anti-bacterial pharmacological experiments.
Service Support: Small laboratory trial lots are stocked. Desiccant-containing sealed packaging is used for shipment to guard against moisture-induced ring hydrolysis. Multiple packing specifications can be customized. COA and HPLC chromatograms are provided with shipments. Our technical team offers guidance on stock solution preparation and stability testing for injectable preclinical formulation projects.
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Product Details

Product Description

 

Biapenem is a 1β-methyl carbapenem class antibacterial compound, designed for laboratory research of bacterial cell wall synthesis inhibition and β-lactam resistance mechanisms. Its unique bicyclic β-lactam chemical skeleton is widely used to prepare bacterial incubation medium to build in-vitro multi-drug resistant pathogen models. Researchers employ this raw powder to examine interactions with penicillin-binding proteins, establish in-vitro bacterial models of severe refractory infection, carry out aqueous solution stability testing, and evaluate its potential as an intermediate for lyophilized injectable formulations.
When sealed under dry and dim ambient storage, this high-purity powder maintains stable physicochemical properties within bacterial test buffer matrices, serving as reliable reference substance for MIC susceptibility assays and aqueous hydrolytic degradation research. It fits early-stage parenteral formulation screening and structural modification exploration of carbapenem antibiotics.

product-1340-1279

COA

 

 

Items Specifications
Appearance Yellow powder
Loss on Drying ≤1.0%
Residue on Ignition ≥0.1%
Lead ≤2 ppm
Arsenic ≤1 ppm
Cadmium ≤1 ppm
Mercury ≤0.1 ppm
Total Aerobic Count ≤1000 CFU/g
Yeast & Mold ≤100 CFU/g
E.Coli, Salmonella Negative
Shelf Life 24 months (sealed and stored away from light)

 

Functions and Effects

 

 

•In-vitro Susceptibility Assay for Drug-resistant Bacterial Strains

Acts as test agent inside bacterial incubation systems to assess inhibitory activity against diverse gram-positive and gram-negative resistant strains during antibacterial pharmacological screening.
•Aqueous Hydrolysis Stability Research of β-lactam Molecules

Works as authenticated reference material to monitor β-lactam ring hydrolytic byproduct generation under variable pH and thermal conditions within cell-free buffered reaction systems.
•Synthetic Scaffold for Carbapenem Derivative Development

Supports medicinal chemistry research as validated chemical skeleton for derivative synthesis and structure-activity relationship exploration of anti-resistance antibacterial candidate compounds.
•Preparation of Buffered Bacterial Susceptibility Culture Medium

Dissolves efficiently in purified water and diluted aqueous buffers, and can be blended with physiological salt solutions to prepare multi-component working buffers for bacterial pharmacology research.

product-1279-1602

 

 

Application Fields

product-1368-1279

 

 

•In-vitro Carbapenem Anti-resistance Mechanism Research Reference reagent for preparing bacterial working solutions for strain susceptibility screening, supporting lead discovery workflows in antibacterial pharmacology.
•Pre-formulation Development of Parenteral Injectable Preparations 

Applied in bench-scale development of injection solution and lyophilized powder, acting as core active raw material to test innovative delivery strategies for injectable antibacterial agents.
•β-lactam Antibiotic Analytical Validation and Related-substance Profiling 

High-purity reference standard for carbapenem impurity detection, aqueous stability comparison and analytical method validation for β-lactam antibiotic raw materials.

 

 

Business Scope

 

 

0421001

 

Packaging And Transportation Methods

 

 

001

 

Certificationss

 

 

222

 

FAQ

 

 

Q1:What research scenarios is Biapenem Powder ≥98.0% suitable for?
A:It is mainly used for in-vitro resistant bacteria inhibition research, β-lactam aqueous hydrolysis stability testing and preliminary injectable formulation feasibility assessment.
Q2:What is its CAS registration number?
A:CAS 120410-24-4.
 
Q3:Can packing weight and purity grade be customized?
A:Yes, net quantity and assay standard can be adjusted to fit your laboratory experimental setup.
 
Q4:Can Biapenem Powder be used for human clinical treatment?
A:This material is restricted to laboratory research only. It is not permitted for human or animal clinical administration.
Q5:What storage guidelines apply to Biapenem raw powder?
A:Keep in hermetically sealed containers with desiccants at ambient temperature. Avoid moisture exposure to prevent β-lactam ring hydrolytic decomposition.
Q6:How does solubility perform in water and organic solvents?
A:Freely soluble in purified water and aqueous buffer; slightly soluble in methanol; poorly dissolved in nonpolar organic solvents.
Q7:Will inter-batch impurity differences interfere with bacterial susceptibility tests?
A:Low-temperature controlled crystallization reduces impurity content; each shipment comes with full related-substance test reports for experimental risk evaluation.
Q8:Are mini trial samples available for initial pharmacological screening?
A:Yes, we provide sample packs ranging from 100mg to 1g for your preliminary in-vitro pharmacological assessment.
 
How To Cooperate With Us?

Our address

No. 56, Jinye 1st Road, Hi-Tech Zone, Xi'an,Shaanxi   Province, China

Phone Number

18192393517

E-mail

dennis04@xaltbio.com

 

product-1145-330

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