Product Description
Clobetasol Propionate is a synthetic potent corticosteroid, designed for investigating cutaneous anti-inflammatory signaling pathways in laboratory settings. Its characteristic steroid tetracyclic backbone makes it widely applied to prepare cell culture media for glucocorticoid receptor-related in-vitro skin cell models. Researchers utilize this raw solid to explore the modulation of inflammatory cytokine release, construct in-vitro epidermal cell models relevant to skin inflammation, run compound stability trials, and validate feasibility for topical pharmaceutical intermediate development.
When kept under sealed dry room-temperature lab storage away from light, this high-purity crystalline powder retains consistent solubility after dissolution in organic solvents. It maintains stable chemical characteristics in ethanolic and aqueous test matrices, delivering dependable reference material for receptor binding assays and chemical degradation studies. It is ideal for early-stage topical formulation screening and exploratory modification of steroid active structures.
COA
| Items | Specifications |
|---|---|
| Appearance | White powder |
| Loss on Drying | ≤2.0% |
| Residue on Ignition | ≥0.5% |
| Lead | ≤1 ppm |
| Arsenic | ≤1 ppm |
| Cadmium | ≤1 ppm |
| Mercury | ≤0.1 ppm |
| Total Aerobic Count | ≤1000 CFU/g |
| Yeast & Mold | ≤100 CFU/g |
| E.Coli, Salmonella | Negative |
| Shelf Life | 24 months (sealed and stored away from light) |
Functions and Effects
◆ In-vitro Assay for Glucocorticoid Receptor Modulation
Acts as a pharmacological additive in epidermal cell incubation systems to assess the regulation of inflammatory mediators during in-vitro dermatopharmacology screening trials.
◆ Evaluation of Small Molecule Hydrolytic Degradation
Serves as certified reference material to track hydrolysis byproduct formation under varied pH and thermal conditions within cell-free organic-aqueous reaction matrices.
◆ Scaffold for Steroid Small Molecule Derivatization
Provides validated small-molecule structural backbone for synthetic chemistry lab work, enabling derivative synthesis and research on structure–activity relationships for topical anti-inflammatory candidates.
◆ Compatibility with Organic-Aqueous Cell Culture Media
Dissolves easily in ethanol and acetone; can be blended with physiological buffers to formulate multi-component working assay buffers for cutaneous cellular pharmacology work.
Application Fields
◆ Mechanism Research of In-vitro Cutaneous Pharmacology
Lab reference reagent for generating skin cell culture working solutions for glucocorticoid receptor screening, supporting iterative formulation screening workflows for dermatology candidate discovery.
◆ Pre-formulation Research for Topical Semi-solid Dosage Forms
Employed in bench-scale formulation development of creams and ointments, acting as core active raw material to test novel delivery strategies for topical steroid compounds.
◆ Analytical Method Validation & Impurity Identification for Small Molecules
High-purity reference standard for impurity profiling, thermal stability comparison tests and benchmark solution validation for pharmaceutical raw material analysis.
Business Scope
Packaging And Transportation Methods
Certificationss
FAQ
Our address
No. 56, Jinye 1st Road, Hi-Tech Zone, Xi'an,Shaanxi Province, China
Phone Number
18192393517
dennis04@xaltbio.com
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