Product Description

Cyclosporine is a cyclic undecapeptide natural product, designed for investigating T-cell mediated immune signaling pathways in laboratory settings. Its distinctive cyclic peptide backbone makes it widely applied to prepare cell culture media for calcineurin-related in-vitro immune cell models. Researchers utilize this raw solid to explore the modulation of T lymphocyte activation, construct in-vitro immune cell models relevant to transplant rejection, run compound stability trials, and validate feasibility for oral solid pharmaceutical intermediate development.
When kept under sealed dry room-temperature lab storage protected from light, this high-purity crystalline powder retains consistent solubility after dissolution in organic solvents. It maintains steady chemical characteristics in organic-aqueous test matrices, delivering dependable reference material for protein binding assays and forced degradation studies. It is ideal for early-stage oral solid formulation screening and exploratory modification of cyclic peptide active structures.

COA

Items	Specifications
Appearance	White powder
Loss on Drying	≤1.0%
Residue on Ignition	≥0.1%
Lead	≤2 ppm
Arsenic	≤1 ppm
Cadmium	≤1 ppm
Mercury	≤0.1 ppm
Total Aerobic Count	≤1000 CFU/g
Yeast & Mold	≤100 CFU/g
E.Coli, Salmonella	Negative
Shelf Life	24 months (sealed and stored away from light)

Functions and Effects

◆ In-vitro Assay for T-Lymphocyte Immune Modulation
Acts as a pharmacological additive in lymphocyte cell incubation systems to assess the inhibition of calcineurin immune signaling during in-vitro immunopharmacology screening trials.

◆ Evaluation of Small Molecule Peptide Hydrolytic Degradation
Serves as certified reference material to track peptide hydrolysis byproduct formation under varied pH and thermal conditions within cell-free organic-aqueous reaction matrices.

◆ Scaffold for Cyclic Peptide Small Molecule Derivatization
Provides validated cyclic peptide structural backbone for synthetic chemistry lab work, enabling derivative synthesis and research on structure–activity relationships for immunosuppressive peptide candidates.

◆ Compatibility with Organic-Aqueous Immune Cell Culture Media
Dissolves easily in ethanol and acetone; can be blended with physiological salts to formulate multi-component working assay buffers for cellular immunopharmacology work.

Application Fields

◆ Mechanism Research of In-vitro Immunopharmacology
Lab reference reagent for generating lymphocyte cell culture working solutions for calcineurin pathway screening, supporting iterative formulation screening workflows for immunosuppressant candidate discovery.

◆ Pre-formulation Research for Oral Solid & Lipid-Based Dosage Forms
Employed in bench-scale formulation development of oral capsules and lipid nanocarriers, acting as core active raw material to test novel delivery strategies for oral immunosuppressive peptide compounds.

◆ Analytical Method Validation & Impurity Identification for Small Molecules
High-purity reference standard for impurity profiling, thermal stability comparison tests and benchmark solution validation for pharmaceutical raw material analysis.

Business Scope

0421001

Packaging And Transportation Methods

001

Certificationss

222

FAQ

Q1: What primary laboratory applications does Cyclosporine Powder ≥99.0% serve?

A1: It is mainly used for in-vitro T-cell immune modulation research, peptide hydrolytic stability testing of small molecules and early oral formulation exploration.

Q2: Can we adjust packing quantity besides standard Research Grade ≥99.0%?

A2: Yes, both net weight and purity grade can be adjusted to match your lab experimental design.

Q3: Can Cyclosporine Powder be used directly for human clinical therapy?

A3: This product is exclusively for laboratory research. It is not approved for human or animal clinical administration.

Q4: What storage recommendations apply to Cyclosporine raw powder?

A4: Store in sealed dry, light-shielded containers at ambient temperature. High humidity and repeated temperature cycling must be avoided to prevent moisture uptake and peptide degradation.

Q5: How does solubility vary between water and organic solvents?

A5: Practically insoluble in purified water; freely soluble in ethanol and acetone; moderately soluble in some polar aprotic solvents; poorly soluble in nonpolar organic solvents.

Q6: Will batch impurity variation interfere with my cellular immune response experiments?

A6: Multi-step low-temperature recrystallization minimizes impurities; each batch comes with complete impurity test reports for your experiment risk assessment.

Q7: Are small trial quantities available for preliminary pharmacological screening?

A7: Yes, we supply 100mg–1g trial packages for your initial in-vitro pharmacological testing.

How To Cooperate With Us?

Our address

No. 56, Jinye 1st Road, Hi-Tech Zone, Xi'an,Shaanxi Province, China

Phone Number

17792692163

E-mail

qinhe06@xaltbio.com

product-1145-330