Diosmin Powder

Diosmin Powder
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Product Name: Diosmin Powder
Alternative Names: 7-[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, citrus flavonoid glycoside lab raw material
Specification: HPLC ≥90% / ≥95%, research grade, adjustable purity available
CAS No.: 520-27-4
Appearance: Greyish-yellow to pale yellow hygroscopic powder. It is almost insoluble in pure water, slightly soluble in ethanol, soluble in DMSO and alkaline aqueous solution. Store under anhydrous and dim ambient environment to avoid oxidation.
Core Advantages: Purification workflow with optional micronization treatment optimizes particle wettability for formulation research. Testing covers heavy metals, residual solvents and microbial limits according to botanical raw material standards. Inter-batch vascular protective bioactivity remains stable. Full flavonoid impurity profiling and mass spectral identification are provided for each lot. Compatible with endothelial cell culture medium to support in-vitro microvascular pharmacological experiments.
Service Support: Small lab trial lots are kept in stock. Moisture barrier sealed packaging is used for shipment to protect this hygroscopic flavonoid substance. Multiple packing specifications can be customized. COA and HPLC fingerprint spectrum are supplied with shipments. Our technical team provides guidance on solubilization approaches and formulation design for poorly soluble flavonoid compounds.
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Product Details

Product Description

 

 

Diosmin is a flavone glycoside extracted and refined from citrus peel, used for laboratory research targeting venous tension regulation and microvascular permeability adjustment. Its unique benzopyranone glycoside chemical skeleton is widely used to prepare endothelial cell incubation medium to construct in-vitro microcirculation cell models. Researchers employ this raw powder to examine endothelial inflammatory signalling pathways, establish cell models of chronic venous insufficiency, carry out oxidative stability testing, and evaluate its potential as an intermediate for vascular health oral formulations.

When sealed under dry and dim ambient storage, this high-purity powder maintains stable physicochemical properties inside vascular simulation buffer matrices, serving as reliable reference substance for endothelial barrier function assays and oxidative degradation research. It fits early-stage oral solid formulation screening and structural modification exploration of flavonoid molecules.

 

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COA

 

 

Items Specifications
Appearance Yellow powder
Loss on Drying ≤1.0%
Residue on Ignition ≥0.1%
Lead ≤2 ppm
Arsenic ≤1 ppm
Cadmium ≤1 ppm
Mercury ≤0.1 ppm
Total Aerobic Count ≤1000 CFU/g
Yeast & Mold ≤100 CFU/g
E.Coli, Salmonella Negative
Shelf Life 24 months (sealed and stored away from light)

 

Functions and Effects

 

 

•In-vitro Endothelial Barrier Function Assay

Acts as test agent inside cell incubation systems to assess regulatory impacts on microvascular permeability during vascular pharmacology screening.
•Oxidative Degradation Stability Research

Works as authenticated reference material to monitor oxidation byproduct generation under variable oxygen concentration and pH conditions within cell-free buffered reaction systems.


•Synthetic Scaffold for Flavonoid Derivative Development Supports phytochemical synthetic research as validated chemical skeleton for derivative synthesis and structure-activity relationship exploration of vascular protective candidate compounds.


•Preparation of Buffered Endothelial Cell Culture Medium 

Dissolves efficiently in alkaline aqueous buffers and DMSO, and can be blended with physiological salt solutions to prepare multi-component working buffers for microvascular cell pharmacology research.

product-1279-1691

 

 

Application Fields

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•In-vitro Microcirculation and Vascular Endothelium Mechanism Research

Reference reagent for preparing endothelial cell working solutions for barrier function screening, supporting lead discovery workflows in venoactive pharmacology.


•Pre-formulation Development of Oral Solid Preparations  Applied in bench-scale development of tablets and capsules, acting as core active raw material to test innovative oral delivery strategies for vascular protective ingredients.


•Phytochemical Raw Material Analytical Validation and Impurity Profiling - High-purity reference standard for flavonoid impurity detection, oxidative stability comparison and analytical method validation for botanical active raw materials.

 

 

Business Scope

 

 

0421001

 

Packaging And Transportation Methods

 

 

001

 

Certificationss

 

 

222

 

FAQ

 

 

Q1:What research scenarios is Diosmin Powder ≥90% suitable for?
A:It is mainly used for in-vitro vascular endothelial protection research, flavonoid oxidative stability testing and preliminary oral solid formulation feasibility assessment.
Q2:What is its CAS registration number?
A:CAS 520-27-4.
 
Q3:Can packing weight and purity grade be customized?
A:Yes, net quantity and assay standard can be adjusted to fit your laboratory experimental setup.
 
Q4:Can Diosmin Powder be used for human clinical treatment?
A:This material is restricted to laboratory research only. It is not permitted for human or animal clinical administration.
Q5:What storage guidelines apply to Diosmin raw powder?
A:Keep in hermetically sealed moisture-proof containers at ambient temperature. Avoid high humidity to prevent hydration and oxidative deterioration.
Q6:How does solubility perform in water and organic solvents?
A:Practically insoluble in purified water; soluble in DMSO and alkaline aqueous solution; slightly soluble in ethanol; poorly dissolved in nonpolar organic solvents.
Q7:Will inter-batch impurity differences interfere with endothelial permeability experiments?
A:Multi-stage purification reduces impurity content; each shipment comes with full impurity test reports for experimental risk evaluation.
Q8:Are mini trial samples available for initial pharmacological screening?
A:Yes, we provide sample packs ranging from 100mg to 1g for your preliminary in-vitro pharmacological assessment.
 
How To Cooperate With Us?

Our address

No. 56, Jinye 1st Road, Hi-Tech Zone, Xi'an,Shaanxi   Province, China

Phone Number

18192393517

E-mail

dennis04@xaltbio.com

 

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